Nafcillin

Nafcillin sodium is a narrow spectrum beta-lactam antibiotic of the penicillin class. As a beta-lactamase-resistant penicillin, it is used to treat infections caused by Gram-positive bacteria, particularly species of staphylococci, that are resistant to other penicillins.

Nafcillin is considered therapeutically equivalent to oxacillin, although its safety profile is somewhat different.

Indications

Nafcillin is particularly indicated in the treatment of staphylococcal infections, except those caused by MRSA.

U.S. clinical practice guidelines recommend either nafcillin or oxacillin as the first-line treatment of choice for staphylococcal endocarditis in patients without artificial heart valves.

Side effects

As with all penicillins, serious life-threatening allergic reactions can occur.

Milder side effects include: Nausea and vomiting
Diarrhea, often due to suppression of normal gastrointestinal bacteria. Occasionally, this leads to a more serious super-infection with an organism like Clostridium difficile
Abdominal pain
Yeast infections (thrush) affecting the mouth and tongue or vagina

Interactions

There is evidence that it induces cytochrome P-450 enzymes.

Translation of "Nafcillin"

Persian: نافسیلین, Italian: Nafcillina.