Mainframe

Mainframe may refer to one of the following:

Mainframe computer, large data processing systems
Mainframe Entertainment, a Canadian computer animation and design company.
Mainframe is the city that the CGI cartoon ReBoot takes place in.
Mainframe (band), a 1980s Electropop band
Mainframe is the name of two fictional characters from Marvel Comics
Mainframe (comics) appears in the series A-Next
Mainframe appears in the Guardians of the Galaxy series
Mainframe (Transformers) is an Autobot character in the Transformers series.
A character in the G.I. Joe universe.
A character from the game Gunman Chronicles.