Gemfibrozil
Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid. Other brand names include Jezil and Gen-Fibro.
Actions
Increases activity of Peroxisome proliferator-activated receptor-alpha (PPARĪ±) 'transcription factor ligand' , a receptor which is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides.
Therapeutic effects
Reduce triglyceride levels
Reduce Very low density lipoprotein (VLDL) levels
Modest reduction of Low density lipoprotein (LDL) levels
Moderate increase in High density lipoprotein (HDL) levels
Nontherapeutic effects and toxicities
GI distress
Musculoskeletal pain
Increased incidence of gallstone
Hypokalemia
Increased risk of cancer[http://www.rxlist.com/cgi/generic/gemfib_wcp.htm]
Indications
Hyperlipidemia (Type III): Gemfibrozil is the drug of choice for therapy.
Hypertriglyceridemia (Type IV): Gemfibrozil, though not as effective as niacin, is better tolerated.
Contraindications and Precautions
Gemfibrozil should not be given to these patients:
Hepatic dysfunction
Renal dysfunction
Gemfibrozil should be used with caution in these higher risk categories:
Biliary Tract Disease
Pregnant women
Obese patients
Native Americans
Drug Interactions
Anticoagulants: Gemfibrozil potentiates the action of coumadin and indanedione anticoagulants.
Statin drugs: Concomitant administration of fibrates (including gemfibrozil) with statin drugs increases the risk of muscle cramping, myopathy, and rhabdomyolysis.
Translation
The word "Gemfibrozil" occurs as such in the following languages: English, Spanish, Italian, Dutch.
Translation(s) in other languages: Polish: Gemfibrozyl, Portuguese: Genfibrozila.
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