Cadaverine
Cadaverine is a foul-smelling molecule produced by protein hydrolysis during putrefaction of animal tissue. Cadaverine is a toxic diamine with the formula NH2(CH2)5NH2, which is similar to putrescine. Cadaverine is also known by the names 1,5-pentanediamine and pentamethylenediamine.
History
Putrescine and cadaverine were first described by the Berlin physician Ludwig Brieger in 1885.
Production
Cadaverine is the decarboxylation product of the amino acid lysine.
However, this diamine is not purely associated with putrefaction. It is also produced in small quantities by living beings. It is partially responsible for the distinctive odors of urine and semen.
Clinical significance
Elevated levels of cadaverine have been found in the urine of some patients with defects in lysine metabolism.
Toxicity
Cadaverine is toxic in large doses. In rats it had a low acute oral toxicity of more than 2000 mg/kg body weight.
Translation
The word "Cadaverine" occurs as such in the following languages: English, Irish, Dutch.
Translation(s) in other languages: Catalan: Cadaverina, Czech: Kadaverin, German: 1,5-Diaminopentan, Spanish: Cadaverina, French: Cadavérine, Galician: Cadaverina, Italian: Cadaverina, Japanese: カダベリン, Polish: Kadaweryna, Portuguese: Cadaverina, Russian: Кадаверин, Finnish: Kadaveriini.
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